To the light, a unique vaccine against malaria
Using live but weakened malaria parasites as the basis of a vaccine can protect themselves from infection. This convinced the researchers, and this shared in the journal Science Express, writes The Times of India.
Parasite that causes malaria is transmitted to humans through the bite of an infected mosquito. After being bitten by a parasite, are being immature, sporozoite, is sent to the liver, where there is duplication, and then spread through the bloodstream throughout the body.
Team led by Stephen L. Hoffman has created a candidate vaccine against the malaria parasite Plasmodium falciparum, clearing these sporozoites and then weakening them with radiation. In a clinical trial, which was attended by 80 healthy volunteers, the vaccine, called PfSPZ, proven safety and efficacy. It caused a small immune response when it was administered intradermally or subcutaneously.
Same tests on animals indicate that intravenous delivery of vaccines can cause a strong immune response in the liver. Also, this method of delivery may be more effective in the prevention of malaria.