A new vaccine against tuberculosis promises actually protect against infection
Injections with modified bacteria, relatives of those that cause tuberculosis, are able to protect against the lung disease, U.S. experts found, reports BBC. Experiments with mice have shown that the injection can completely kill the TB bacteria.
The currently existing vaccine against tuberculosis is not has high efficiency (it ranges from 0% to 80%). Meanwhile, TB – one of the most common causes of death, according to the statistics, driven by WHO. It kills 1.7 million people every year.
Staff of Albert Einstein College of Medicine in New York in the same vaccine have turned their attention to the study of the cluster of genes called esx-3, whose variations are found in all types of mycobacteria, provoking the development of tuberculosis, and allows microorganisms to avoid the immune system.
Mycobacterium tuberculosis bacteria can not survive without the esx-3 genes, but their relative Mycobacterium smegmatis can. Scientists removed the genes M. smegmatis and introduced into mice a lethal dose of the bacteria. For three days, the rodents managed to get rid of bacteria in the kidneys and lungs. Next, the researchers tried to introduce genes esx-3 M. in M. tuberculosis Smegmatis. The mixture dubbed Ikeplus.
A result, the rodents could still quickly get rid of the infection Ikeplus, but as a result they have remained long lasting immunity against M. tuberculosis. But the mice infected with TB bacteria but have not received the vaccine, on average died after 54 days. Moreover, animals vaccinated conventional vaccine, lived 65 days, and mice vaccinated Ikeplus, – 135 days.